Actor Eric Dane, widely known for his roles in Grey’s Anatomy and Euphoria, has died at the age of 53 following a battle with amyotrophic lateral sclerosis (ALS).
His family confirmed that the California-born actor passed away on Thursday afternoon after what they described as a courageous fight against the progressive neurological disease, which he publicly disclosed in April 2025.
Dane rose to global fame for portraying Dr. Mark Sloan affectionately nicknamed “Dr. McSteamy” in Grey’s Anatomy, first appearing in 2006 before becoming a main cast member.
In recent years, he played Cal Jacobs, the complex patriarch in HBO’s hit drama Euphoria.
In a statement, his family said he spent his final moments surrounded by loved ones, including his wife, actress Rebecca Gayheart, and their two daughters, Billie and Georgia.
Career and Legacy
Born in San Francisco in 1972, Dane made his television debut in The Wonder Years in 1993 and went on to build a diverse acting career.
He appeared in the supernatural series Charmed, starred as Captain Tom Chandler in The Last Ship, and featured in films such as Marley & Me, Valentine’s Day, and Burlesque.
Tributes poured in from colleagues and friends across the entertainment industry. Kim Raver, his Grey’s Anatomy co-star, praised his comedic timing and presence on set, while Kevin McKidd posted a brief tribute on social media, writing, “Rest in peace, buddy.”
Euphoria creator Sam Levinson described working with Dane as an honour, adding that their friendship was a gift.
Other tributes came from Alyssa Milano, Ashton Kutcher and Nina Dobrev, who remembered him as warm, kind and deeply devoted to his family.
Advocacy and Final Months
Following his diagnosis, Dane became an advocate for ALS research and awareness, working with the nonprofit Target ALS and helping fundraising efforts surpass $500,000.
He also appeared in campaigns and interviews urging progress toward treatments and a cure.
Earlier this year, he was named among Time magazine’s 100 most influential people in health for his advocacy work.
Understanding ALS
Amyotrophic lateral sclerosis, also known as motor neurone disease (MND) or Lou Gehrig’s disease, is a progressive neurological condition that causes muscle weakness and paralysis.
There is currently no cure, and most patients live three to five years after diagnosis.
Dane’s family said he remained grateful for the support he received from fans worldwide and will be remembered for both his on-screen legacy and his efforts to raise awareness about the disease
